CRISPR-Cas systems are best known as adaptive immune defences that protect bacteria and archaea from invading genetic elements—but their biology, diversity and applications reach far beyond targeted DNA cleavage. In this FEMS webinar, featuring authors from microLife, researchers will explore three complementary perspectives on these remarkable systems.
Discover how time-lapse imaging can reveal heterogeneous bacterial growth during Type IV-A1 CRISPR activity, even when defence occurs without degradation of target DNA. Learn how Type II-C systems use distinct molecular strategies to limit potentially disruptive extraneous CRISPR RNAs and optimize immune function. Finally, see how MCAAT, a sensitive assembly-free tool, identifies CRISPR arrays directly from metagenomic data, opening new opportunities to uncover system diversity and investigate spacer evolution.
Bringing together experimental microbiology, bioinformatics and innovative imaging, this webinar offers researchers and students a concise view of how new methods are advancing CRISPR-Cas discovery and deepening our understanding of microbial defence. |
